PMID- 36169272 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Quintessence Int JT - Quintessence International IS - 1936-7163 (Electronic) IP - 10 VI - 53 PST - ppublish DP - 2022 PG - 832-838 LA - en TI - Five-year results following regenerative periodontal surgery with an enamel matrix derivative in patients with different smoking status LID - 10.3290/j.qi.b3418233 [doi] FAU - De Ry, Siro Pietro AU - De Ry S FAU - Pagnamenta, Marco AU - Pagnamenta M FAU - Ramseier, Christoph Andreas AU - Ramseier C FAU - Roccuzzo, Andrea AU - Roccuzzo A FAU - Salvi, Giovanni Edoardo AU - Salvi G FAU - Sculean, Anton AU - Sculean A CN - OT - enamel matrix derivative (EMD) OT - intrabony defects OT - long-term results OT - periodontal regeneration OT - regenerative periodontal surgery OT - smoking AB - Objective: To evaluate the five-year results following regenerative periodontal surgery of intrabony defects using an enamel matrix derivative (EMD) in patients with different smoking status. Method and materials: The dental records of patients treated with regenerative periodontal surgery with EMD between 2001 and 2011 were screened. The clinical parameters at baseline (T0) and 6 months (T1) and 5 years (T2) after surgery were collected and analyzed in relation to patient’s smoking status (smokers, former smokers, and nonsmokers). Results: A total of 71 sites were initially assessed in 38 patients. In total, 56 sites could be evaluated at T1, and 34 after 5 years (T2). At 6 months after surgery, a statistically significant mean probing pocket depth (PPD) reduction of 2.91 ± 1.60 mm and a mean clinical attachment level (CAL) gain of 1.89 ± 1.90 mm were measured. Nonsmokers revealed a greater, statistically not significant CAL gain compared to smokers (2.38 ± 2.12 mm vs 1.50 ± 1.71 mm). Although at 5 years the site-specific PPD values remained stable in nonsmokers, smokers showed an increase of 1.60 ± 2.41 mm. Conclusions: The present study provides evidence that regenerative periodontal surgery with EMD may lead to clinically relevant improvements even in smoking patients. However, the positive effect of EMD seems to be limited in time and can only partially compensate for the negative influence of smoking. AID - 3418233