PMID- 16642908 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Int J Periodontics Restorative Dent JT - International Journal of Periodontics & Restorative Dentistry IS - 1945-3388 (Electronic) IS - 0198-7569 (Print) IP - 2 VI - 26 PST - ppublish DP - 2006 PG - 190-196 LA - en TI - Molecular Changes in the Gingival Epithelium Associated with Necrotizing Ulcerative Periodontitis: A Case Report FAU - Dannewitz, Bettina AU - Dannewitz B FAU - Eickholz, Peter AU - Eickholz P FAU - Kohl, Annette AU - Kohl A FAU - Komposch, Gerda AU - Komposch G FAU - Tomakidi, Pascal AU - Tomakidi P CN - AB - A case of necrotizing ulcerative periodontitis (NUP), the most severe inflammatory periodontal disorder caused by plaque bacteria, is shown. Clinically, the gingiva showed distinct signs of ulceration, and radiography revealed horizontal bone loss. Indirect immunofluorescence, carried out on frozen sections of tissue specimens obtained from the NUP lesion, exhibited clear expression of atypical keratin K19, particularly in basal cells, when compared to noninflamed gingiva. Moreover, NUP tissue showed extensive intraepithelial abundance for the basement membrane component laminin-1/10 and the extracellular matrix molecule tenascin. Strong expression of integrin subunit αv and matrix metalloproteinase-13 in conjunction with interleukin 1-beta further discriminated NUP gingival epithelium from normal tissue. The results suggest that NUP is associated with changes in the expression and topography of the analyzed molecules in the gingival epithelium, which in turn may reflect the fast progression of the disease. AID - 853191