OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Int Poster J Dent Oral Med JT - International Poster Journal of Dentistry and Oral Medicine IS - 1612-7749 (Electronic) IP - 3 VI - 18 PST - ppublish DP - 2016 PG - 0-0 LA - en TI - Microarray Analysis of Peri-implant Tissue Behavior Next to Different Titanium Implant Surfaces FAU - Dellepiane, Elena AU - Dellepiane E FAU - Menini, Maria AU - Menini M FAU - Baldi, Domenico AU - Baldi D FAU - Izzotti, Alberto AU - Izzotti A FAU - Canepa, Paolo AU - Canepa P FAU - Pera, Paolo AU - Pera P CN - OT - dental implants OT - peri-implant tissue OT - microRNA OT - titanium surfaces AB - Purpose: The aim of this split-mouth study was to evaluate the behaviour of soft and hard tissue around implants with two different surface treatments. Materials and methods: 10 patients (5 men, 5 women) were treated with fixed partial dentures supported by implants. Each patient received at least 2 implants (1 control, 1 test) into an edentulous quadrant. The control implants (Osseotite, OSS) had a dual acid-etched (DAE) surface in the apical portion and a machined coronal part; test implants (Full Osseotite, FOSS) had a completely DAE surface. Machined healing abutments were placed on control implants and DAE abutments on test ones. After 3 months from surgery, a mini-invasive sample of soft tissue was collected from the first 7 patients recruited for the study (4 women and 3 men). The samples were analysed by microRNA (miRNA) microarray. Standardised periapical radiographs were taken to investigate interproximal bone levels at baseline (immediately after implant insertion), 2 months, 6 months, and 1 year post-implant placement. Plaque index (PI), bleeding on probing (BOP) and periodontal depth (PD) were recorded at 3 and 6 weeks, and at 2, 3, 6 and 12 months post-implant placement. Differences in bone resorption over time were evaluated with the Friedman test followed by post-hoc Wilcoxon signed ranks tests. Differences in bone resorption, PI, BOP and PD between the two types of implant over time were assessed by the repeated measures ANOVA test for ranked data. A p ≤0.05 was considered statistically significant. Statistical analyses were carried out with SPSS v.20. Microarray data were processed by GeneSpring® software and their overall variability was examined by box-plot analysis, scatter-plot analysis, hierarchical cluster analysis (HC) and principal component analysis (PCA). Individual miRNAs modulated by the experimental treatments were identified by volcano-plot (thresholds 2-fold and P AID - 857485