PMID- 33491381 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Oral Health Prev Dent JT - Oral Health and Preventive Dentistry IS - 1757-9996 (Electronic) IP - 1 VI - 19 PST - epublish DP - 2021 PG - 77-83 LA - en TI - Periodontal Diseases and Adverse Pregnancy Outcomes: Review of Two Decades of Clinical Research LID - 10.3290/j.ohpd.b898969 [doi] FAU - Pockpa, Zocko Ange Désiré AU - Pockpa Z FAU - Soueidan, Assem AU - Soueidan A FAU - Koffi-Coulibaly, Nadin Thérèse AU - Koffi-Coulibaly N FAU - Limam, Alexandre AU - Limam A FAU - Badran, Zahi AU - Badran Z FAU - Struillou, Xavier AU - Struillou X CN - OT - periodontal diseases OT - pregnancy OT - adverse pregnancy outcomes OT - mapping AB - Purpose: The aim of this study was to review the literature and chart the clinical studies that have focused on periodontal diseases and adverse pregnancy outcomes since 1996. Materials and Methods: Medline, Cinahl, and Cochrane databases were searched for original studies focused on pregnancy outcomes and periodontal status in humans. The most recent search was conducted on April 30, 2020. Results: Of the 633 articles identified, 232 articles (n = 119,774 participants) were selected for analysis. The majority of studies highlighted a statistically significant association between periodontal diseases and preterm birth (71 of 111 articles; 63.96%), low birth weight (46 of 64 articles; 71.87%), preterm low birth weight (29 of 49 articles; 59.18%), preeclampsia (31 of 45 articles; 68.89%) and other pregnancy complications, such as preterm, prelabor rupture of membranes (17 of 26 articles; 65.38%). Geographical analysis revealed that clinical studies were conducted in 51 countries, primarily in the United States (42 studies, 18.10%), Brazil (33 studies, 14.22%) and India (25 studies, 10.78%). Irrespective of geographical location, analysis showed various degrees of evidence of a relationship between periodontal diseases and adverse pregnancy outcomes. Conclusion: The majority of the studies found a statistically significant link between periodontal diseases and some complications of pregnancy. The strength of such a link varies according to type of study, type of variable and outcome measure selected. AID - 898969