PMID- 35293708 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Chin J Dent Res JT - Chinese Journal of Dental Research IS - 1867-5646 (Electronic) IS - 1462-6446 (Print) IP - 1 VI - 25 PST - ppublish DP - 2022 PG - 29-36 LA - en TI - Microspheres and their Potential in Endodontic Regeneration Application LID - 10.3290/j.cjdr.b2752709 [doi] FAU - YANG, Ting AU - YANG T FAU - XIE, Li AU - XIE L FAU - ZHANG, Rui Tao AU - ZHANG R FAU - TIAN, Wei Dong AU - TIAN W CN - OT - dental pulp OT - endodontic regeneration OT - microcapsules OT - microcarriers OT - microspheres AB - Microspheres have been widely utilised as versatile carriers in biomedical applications. In recent years, as a new type of injectable scaffold, microspheres have attracted increasing attention in the field of regenerative medicine owing to their various advantages including their small size, large specific surface area and mimicry of the 3D native environment. These characteristics enable them to adopt the narrow and irregular anatomy of the tooth and become an ideal scaffold for endodontic regeneration. Microspheres play an important role in carrying biologics (cells, biomolecules and drugs), which effectively regulate the fate of stem cells and control the release of growth factors and drugs. Cell-laden microspheres, which can be divided into microcarriers and microcapsules, have great application prospects in dental pulp regeneration. This paper summarises the properties and characteristics of microsphere scaffolds used in tissue engineering, placing emphasis on their advantages and applications in endodontic regeneration. AID - 2752709