OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Oral Health Prev Dent JT - Oral Health and Preventive Dentistry IS - 1757-9996 (Electronic) IP - 4 VI - 2 PST - ppublish DP - 2004 PG - 369-376 LA - en TI - An Experimental Gingivitis Study to Evaluate the Clinical Effects of a Stannous Fluoride Dentifrice LID - 10.3290/j.ohpd.a9764 [doi] FAU - Lang, Niklaus P. AU - Lang N FAU - Anton, Elena AU - Anton E FAU - Gabriel, Yvonne AU - Gabriel Y FAU - Pjetursson, Bjarni E. AU - Pjetursson B FAU - Winston, Leslie J. AU - Winston L FAU - He, Tao AU - He T CN - OT - prevention OT - gingivitis OT - stannous fluoride OT - dentifrice OT - plaque OT - discolorations AB - A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis. Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) Colgate® Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer). After three weeks, the stannous fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the Colgate® Total group by 39.7%. Gingival bleeding was also reduced relative to the Colgate® Total group. This difference was statistically significant (P < 0.05). During the experimental period, the mean PlI scores increased almost linearly in all three groups without yielding any statistically significant differences. The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate® Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/copolymer (Colgate® Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices. AID - 841456