OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Oral Health Prev Dent JT - Oral Health and Preventive Dentistry IS - 1757-9996 (Electronic) IP - 1 VI - 3 PST - ppublish DP - 2005 PG - 3-8 LA - en TI - The Effect of LongoVital on Recurrent Aphthous Stomatitis in a Controlled Clinical Trial LID - 10.3290/j.ohpd.a10069 [doi] FAU - Bratel, John AU - Bratel J FAU - Hakeberg, Magnus AU - Hakeberg M FAU - Jontell, Mats AU - Jontell M CN - OT - recurrent aphthous stomatits OT - LongoVital OT - immunostimulation AB - Purpose: The aim of this study was to evaluate the effect of daily intake of LongoVital (LV) (herbal vitamin tablets) in the prevention of RAS. Materials and Methods: A group of 78 consecutively referred patients was enrolled to a three-months pretreatment period. Fifty subjects were then randomly allocated to an LV-group (n = 25) or a placebo group (N = 25). A double blind, stratified-randomised clinical case-control study was performed during six months. Number and size of the ulcers were registered by the patients using a standardized chart. The degree of discomfort was recorded on a 100 mm horizontal visual analogue scale (VAS-scale). Results: The three-months pretreatment period revealed that the most dominant symptoms were pain (78%) followed by burning sensation (18%). No significant differences between the two groups were found during this period when a comparison was made at the end of the study. After the intervention period the number of aphthous ulcers/month decreased significantly in the LV-group (p = 0,02). The number of days in pain/month were also reduced (p < 0,001). If a 50% reduction of number of aphthous ulcers and days in pain were considered as clinically relevant, no statistical significant differences were found between the groups. Conclusion: Thus, no strong evidence was found that justified a recommendation of LV as a general drug for treatment of RAS. AID - 841461