PMID- 32515413 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Oral Health Prev Dent JT - Oral Health and Preventive Dentistry IS - 1757-9996 (Electronic) IP - 1 VI - 18 PST - epublish DP - 2020 PG - 433-440 LA - en TI - Preoperative Mouthwash in Subjects with Different Periodontal Status: A Randomised Controlled Clinical Trial LID - 10.3290/j.ohpd.a44308 [doi] FAU - Máximo, Priscila de Macedo AU - Máximo P FAU - Cortelli, Sheila Cavalca AU - Cortelli S FAU - Aquino, Davi Romeiro AU - Aquino D FAU - de Miranda, Taís Browne AU - de Miranda T FAU - Costa, Fernando Oliveira AU - Costa F FAU - Cortelli, José Roberto AU - Cortelli J CN - OT - anti-infective agents OT - mouthwashes OT - periodontal diseases OT - single dose AB - Purpose: The effects of three preoperative mouthwashes on salivary bacterial levels were evaluated and compared between subjects with differing periodontal status. Materials and Methods: Based on periodontal parameters, periodontally healthy individuals (n = 60) and those with gingivitis (n = 60) and periodontitis (n = 60) were randomly assigned to a single preoperative dose of chlorhexidine (CHX), essential oils (EO), cetylpyridinium chloride (CPC) or negative control mouthwashes. Saliva samples were collected between 8:00 and 11:00 a.m., before and after a single-dose rinse with the respective mouthwash. Total bacterial load and levels of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and Streptococcus oralis were determined by qPCR. Data were statistically analysed using paired t- and Student's t-tests (p < 0.05). Results: CHX, EO and CPC showed greater antimicrobial efficacy than did the negative control. CHX [1226445.53] and EO [1743639.38] provided greater reductions in comparison to both CPC [106302.96] and negative control [37852.46]). CHX provided greater reductions of simultaneous levels of Pg [106326.00], Td [3335841] and Tf [61557.47] in the healthy group, as did EO in the diseased groups. CPC provided the greatest reduction [3775319.36] in the periodontitis group. Conclusion: Periodontal status influenced the antimicrobial efficacy of preoperative mouthwashes. Therefore, periodontal status should be taken into consideration by clinicians. The antimicrobial efficacy differed among the agents tested. CHX and EO showed the greatest efficacy. The recognition of periodontal condition by clinicians is mandatory to select the most effective preoperative mouthwash. AID - 842315