PMID- 27183063 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Int J Oral Maxillofac Implants JT - The International Journal of Oral & Maxillofacial Implants IS - 1942-4434 (Electronic) IS - 0882-2786 (Print) IP - 3 VI - 31 PST - ppublish DP - 2016 PG - 547-554 LA - en TI - Titanium-Zirconium Binary Alloy as Dental Implant Material: Analysis of the Influence of Compositional Change on Mechanical Properties and In Vitro Biologic Response LID - 10.11607/jomi.4349 [doi] FAU - Lee, Tsunglin James AU - Lee T FAU - Ueno, Takeshi AU - Ueno T FAU - Nomura, Naoyuki AU - Nomura N FAU - Wakabayashi, Noriyuki AU - Wakabayashi N FAU - Hanawa, Takao AU - Hanawa T CN - OT - alloy composition OT - biologic response OT - dental implant material OT - mechanical property OT - titaniumzirconium alloy AB - Purpose: To evaluate the mechanical properties and biologic response of single-phase Ti-Zr alloys cast in higher-purity casting conditions, with comprehensive compositions (from 10 to 90 mol% of Zr). Materials and Methods: The mechanical properties and in vitro biologic response with proportional increase of Zr to Ti-Zr alloy composition were assessed. Tensile strength, surface hardness, and Young's modulus were examined. The in vitro cell response of the alloys was also tested with mouse osteoblast cells. Results: Analyses of mechanical tests demonstrated improved strength and reduced Young's modulus on this binary alloy system. In vitro cell culture studies with osteogenic MCT3T-E1 cells exhibited the highest attachment rate with the largest and more mature cells on Ti10Zr, instead of commercially pure Ti, whereas a significantly lower cell attachment rate and delayed alkaline phosphatase-specific activity (ALP) differentiation were detected on Ti50Zr. Conclusion: The results revealed that the composition did have an impact on the in vitro biologic response. Ti-Zr alloys with 50-50 mol% composition had a decreased biologic response, although the mechanical properties improved. The overall highest strength was Ti with 30 mol% Zr without significant decrease of biologic response. AID - 846746