PMID- 32406664 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Int J Oral Maxillofac Implants JT - The International Journal of Oral & Maxillofacial Implants IS - 1942-4434 (Electronic) IS - 0882-2786 (Print) IP - 3 VI - 35 PST - ppublish DP - 2020 PG - 639-644 LA - en TI - Zirconium Implant as an Alternative to Titanium Implant in a Case of Type IV Titanium Allergy: Case Report LID - 10.11607/jomi.7990 [doi] FAU - Tawil, Georges AU - Tawil G FAU - Tawil, Peter AU - Tawil P FAU - Irani, Carla AU - Irani C CN - OT - osseointegration OT - titanium allergy OT - zirconium implants AB - Titanium remains the material of choice in the manufacturing of dental implants because of its exceptional biologic and mechanical properties. However, cases of allergy to titanium have been reported in the literature causing skin, mucosal reactions, systemic symptoms, and eventually implant exfoliation. Although the frequency of these cases varied between 0.6% and 5%, undiagnosed or misdiagnosed cases may possibly increase this percentage significantly. Epicutaneous, intradermal inoculation of the allergen or blood tests (LTT, MELISA, IL1β, IL-6, TNF-α, IL-10) have been used with various degrees of sensitivity and specificity to assess Ti allergy. This case report demonstrated that titanium dental implant allergy caused rapid implant loss following an acute inflammatory reaction and its successful replacement by a one-piece zirconium implant. AID - 847496