PMID- 30180236 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Int J Prosthodont JT - The International Journal of Prosthodontics IS - 1942-4426 (Electronic) IS - 0893-2174 (Print) IP - 5 VI - 31 PST - ppublish DP - 2018 PG - 481-484 LA - en TI - Effect of Over-the-Counter Topical Agents on Denture-Induced Traumatic Lesions: A Clinical Study LID - 10.11607/ijp.5803 [doi] FAU - Bural, Canan AU - Bural C FAU - Güven, Melahat Çelik AU - Güven M FAU - Kayacıoğlu, Büşra AU - Kayacıoğlu B FAU - Ak, Gülsüm AU - Ak G FAU - Bayraktar, Gülsen AU - Bayraktar G FAU - Bilhan, Hakan AU - Bilhan H CN - AB - Purpose: To investigate the effects of over-the-counter products on the healing of dentureinduced ulcerations and patients' self-reported pain. Materials and Methods: A total of 140 patients with acute denture-induced ulcerations were randomized into seven treatment groups: denture grinding (control); topical application of corn oil gel (placebo); triester glycerol oxide gel; D-panthenol gel; D-panthenol mouthwash; L-arginine mouthwash; and hyaluronic acid gel. Healing and self-reported pain were assessed after 1, 3, and 7 days of treatment. Results: The percentage of healed lesions in the mandible and maxilla after 7 days was 67% and 65%, respectively. The only significance in healing was for mandibular lesions at 3 days after application of L-arginine mouthwash; at this period, the healing rate was significantly higher than d-panthenol gel, d-panthenol mouthwash, and hyaluronic acid gel (P < .05). Conclusion: Denture grinding as the current protocol for acute denture-induced ulcerations should remain as the default. AID - 850033