OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - J Orofac Pain JT - Journal of Oral & Facial Pain and Headache IS - 2333-0376 (Electronic) IS - 2333-0384 (Print) IP - 1 VI - 26 PST - ppublish DP - 2012 PG - 26-32 LA - en TI - Topical Nonsteroidal Anti-inflammatory Medications for Treatment of Temporomandibular Joint Degenerative Pain: A Systematic Review FAU - Senye, Mireya AU - Senye M FAU - Mir, Carlos Flores AU - Mir C FAU - Morton, Stephanie AU - Morton S FAU - Thie, Norman M. R. AU - Thie N CN - OT - anti-inflammatories OT - osteoarthritis OT - systematic review OT - temporomandibular joint OT - topical nonsteroidal AB - Aims: To evaluate the efficacy of topical nonsteroidal antiinflammatory drugs (NSAID) to relieve temporomandibular joint (TMJ) degenerative joint disease (DJD) pain. Methods: A search of the literature was made using electronic databases complemented with a manual search. Clinical trials comparing topical NSAID with either placebo or an alternative active treatment to treat TMJ DJD pain were identified. Outcomes evaluated were pain reduction/pain control and/or incidence of side effects. Results: A single study (double-blind randomized placebo-controlled trial) with 20 patients was identified that evaluated the efficacy of a topically prepared NSAID over a 12-week duration, measuring functional pain intensity, voluntary and assisted mouth opening, pain disability index, and a brief pain inventory analysis. This study revealed a pain intensity decrease within treatment groups but no significant difference between treatment groups. Conclusion: Presently, there is insufficient evidence to support the use of topically applied NSAID medications to palliate TMJ DJD pain. AID - 851069