PMID- 27977821 OWN - Quintessenz Verlags-GmbH CI - Copyright Quintessenz Verlags-GmbH OCI - Copyright Quintessenz Verlags-GmbH TA - Int J Periodontics Restorative Dent JT - International Journal of Periodontics & Restorative Dentistry IS - 1945-3388 (Electronic) IS - 0198-7569 (Print) IP - 1 VI - 37 PST - ppublish DP - 2017 PG - 79-86 LA - en TI - A Possible Link Between Rheumatoid Arthritis and Periodontitis: A Systematic Review and Meta-analysis LID - 10.11607/prd.2656 [doi] FAU - Tang, Qingqin AU - Tang Q FAU - Fu, Haitao AU - Fu H FAU - Qin, Baodong AU - Qin B FAU - Hu, Zhide AU - Hu Z FAU - Liu, Yaoting AU - Liu Y FAU - Liang, Yan AU - Liang Y FAU - Zhou, Lin AU - Zhou L FAU - Yang, Zaixing AU - Yang Z FAU - Zhong, Renqian AU - Zhong R CN - AB - Previous studies have shown that patients with rheumatoid arthritis (RA) have a higher susceptibility to periodontitis, but the results of individual studies remain controversial. The aim of the present meta-analysis was to comprehensively evaluate the association between RA and periodontitis. A systematic literature search was conducted in PubMed and EMBASE. Data were extracted using standardized forms, and odds ratios (OR) with 95% confidence intervals (CI) were calculated for each study. Pooled data were estimated by fixed- and randomeffects models if appropriate. Eight case-control studies were included in the present study. Study size ranged from 104 to 151,569 participants. The prevalence of periodontitis in RA patients ranged from 15.5% to 100%, compared with 10.0% to 82.1% in controls. In group 1 (control) and group 2, the heterogeneity was 38% and 11%, respectively. Using fixed-effects analysis, the overall pooled estimates of the ORs for periodontitis were 4.68 (95% CI: 3.11-7.05) and 1.28 (95% CI: 1.24-1.33) in groups 1 and 2, respectively. This meta-analysis indicates that RA was significantly associated with increased overall risk of periodontitis. AID - 854128