This case report emphasizes how home and professional care can impact clinical outcomes following nonsurgical mechanical therapy with the adjunctive use of a diode laser to treat failing implants. Localized severe peri-implant disease was diagnosed in a patient who was susceptible to periodontal disease, not compliant, and did not accept the surgical approach. A cause-related, diode laser-assisted, nonsurgical treatment was therefore implemented, according to a dedicated protocol, in four closely scheduled appointments. The patient's oral hygiene skills became extremely effective. She then adhered to a bimonthly maintenance protocol in the first follow-up year and quarterly in the subsequent year. Bone remineralization was detected on comparative periapical radiographs 2 years after the diagnosis of peri-implantitis. At the 2-year observation, the patient's high standard of home care and dedicated maintenance arrested the progression of peri-implantitis and yielded clinical and radiographic improvements following nonsurgical mechanical therapy with adjunctive repeated application of a diode laser.