Deep subgingival margins are a much-debated topic in adhesive and restorative dentistry. The hydrophobic trait of direct composite resin materials challenges the restorative procedure of cavities with deep subgingival margins since isolation is complicated. A correct indication for a deep margin elevation (DME) treatment is the key to its clinical success, and adequate adaptation of the DME is crucial to its clinical performance. An adequate adaptation of the DME may potentially reduce bacterial accumulation and reduce the incidence of secondary caries as well as maintain periodontal health. The present case report aims to provide a step-by-step overview of the DME technique when applied in combination with a partial indirect glass-ceramic restoration and also provides clinical guidelines to tackle deep subgingival cavities. The indication for a DME and the selection of appropriate materials are explained, supported by the literature.