PMID- 35285598 OWN - Quintessence Publishing Company, Ltd. CI - Copyright Quintessence Publishing Company, Ltd. OCI - Copyright Quintessence Publishing Company, Ltd. TA - Oral Health Prev Dent JT - Oral Health and Preventive Dentistry IS - 1757-9996 (Electronic) IP - 1 VI - 20 PST - epublish DP - 2022 PG - 103-112 LA - en TI - Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups LID - 10.3290/j.ohpd.b2805419 [doi] FAU - Almalki, Abdullah AU - FAU - Thomas, Julie Toby AU - Thomas J FAU - Salama, Mohamed Helmy AU - Salama M FAU - Alghamdi, Sara Ayid AU - Alghamdi S FAU - Almulhim, Basim AU - Almulhim B FAU - Alassaf, Abdullah AU - Alassaf A FAU - Joseph, Betsy AU - Joseph B FAU - Alqerban, Ali AU - Alqerban A CN - OT -  C-terminal telopeptide region of type I collagen OT - IGF-binding protein-3 OT - insulin-like growth factors OT - periodontitis OT - skeletal maturity AB - Purpose: To compare the levels of salivary IGF-1, IGFBP-3, and CTX with periodontal status among patients belonging to various skeletal maturity groups. Materials and Methods: This cross-sectional study was conducted on 80 participants 6 to 25 years of age. Based on skeletal maturity, the participants were categorised into 3 different stages: prepubertal, pubertal, and post-pubertal stages. The periodontal status of the participants was assessed using the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). The saliva samples were examined for IGF-1, IGFBP-3, and CTX using the respective ELISA kits. One-way ANOVA was used to determine statistically significant differences of means across the study groups for continuous variables. Results: The study demonstrated statistically significant differences for the parameters OHI-S, bleeding on probing, PPD, CPI, and CAL (p < 0.05) depending on skeletal maturity stage. ANOVA test showed a statistically significant difference by stage in IGF-1, IGFPB3, and CTX (p < 0.01). Conclusion: An association exists between periodontal status and levels of salivary IGF-1, IGFBP-3, and CTX in patients belonging to various skeletal maturity groups. AID - 2805419