OWN - KVM - Der Medizinverlag CI - Copyright KVM - Der Medizinverlag OCI - Copyright KVM - Der Medizinverlag TA - Int J Oral Maxillofac Implants JT - The International Journal of Oral & Maxillofacial Implants IS - 1942-4434 (Electronic) IS - 0882-2786 (Print) IP - 6 VI - 35 PST - ppublish DP - 2020 PG - 1122-1131 LA - en TI - A Novel Xenograft Bon e Substitute Supports Stable Bone Formation in Circumferential Defects Around Dental Implants in Minipigs FAU - Catros, Sylvain AU - Catros S FAU - Sandgren, Rebecca AU - Sandgren R FAU - Pippenger, Benjamin E AU - Pippenger B FAU - Fricain, Jean Christophe AU - Fricain J FAU - Herber, Valentin AU - Herber V FAU - El Chaar, Edgard AU - El Chaar E CN - OT - Bio-Oss OT - bone formation OT - bone-to-implant contact OT - cerabone OT - circumferential defect OT - demineralized bovine bone AB - Purpose: The aim of this study was to evaluate and compare bone growth and implant integration in circumferential defects with two commercially available bone substitutes (demineralized bovine bone mineral [DBBM]). Materials and Methods: Circumferential defects were created in the mandibles of minipigs (n = 10), and Bone Level Tapered implants (Straumann Roxolid with SLActive surface) were placed. The defects (4-mm-deep circumferential defect, 2 mm around each implant) were augmented with either sintered bovine bone mineral (test, cerabone) or natural bovine bone mineral (control, Bio-Oss). Bone formation and tissue composition in augmented sites were histomorphometrically assessed after 8 and 12 weeks of healing time (n = 5 each), respectively, in terms of the percentage of area of newly formed bone to total area, bone-to-implant contact (BIC), and crestal bone height relative to the implant shoulder (first bone-to-implant contact [fBIC]). Results: Bone formation in all defect sites was adequate and equivalent for both groups at individual healing time points. The amount of residual graft material was comparable in both groups after 8 and 12 weeks, with no significant resorption in either group. The mean newly formed bone area in the test group amounted to 46.7% ± 5.1% and 48.7% ± 4.0% after 8 and 12 weeks vs 47.0% ± 4.8% and 47.8% ± 7.3% in the control group, respectively. BIC and fBIC as individually assessed for the lingual and buccal aspects were comparable at both healing time points without any statistically significant differences between the groups. A slightly greater variability of fBIC was observed within the test group. Conclusion: The results of this study indicate that test and control materials both represent viable bovine bone graft material that equivalently support the formation of new and stable bone volume specifically when used for simultaneous augmentation around implants. AID - 875927