Missing canines compromise function and esthetics and therefore should be restored. In case of a retained canine, there can be a conservative approach of classic orthodontic eruption. If that is not effective, an alternative treatment method is to remove the retained tooth, followed by implant placement or transalveolar autotransplantation of the retained canine. En bloc autotransplantation of a retained canine, with surrounding bone, preserves canine periodontium and increases chances for revascularization and vitality of the transplanted tooth. This paper presents an en bloc autotransplantation of retained canines in the mandible in two female patients resulting in canine vitality after 1.5 years with proper pocket depth, physiologic tooth mobility, and positive reaction to ethyl chloride.