Purpose: To describe a chairside method for producing implant guides based solely on digital data and present a first assessment of in vitro accuracy on plaster models. Material and Methods: Twenty-four implants were planned and pilot drillings were performed according to a new protocol, which is based on the registration of CBCT and CAD/CAM data. Chairside-milled one-piece drill guides were used to transfer the virtual plan into reality. Accuracy measurements were acquired. Results: Chairside-milled drill guides were successfully fabricated and accuracy for pilot drillings was between 0.17 and 1.3 mm. Conclusion: Within the limits of this experimental study, chairside-milled drill guides are feasible and do not require any preparation before CBCT scanning. Keywords: accuracy, dental implantology, cone-beam computed tomography (CBCT), dental CAD/CAM, computer-aided surgery (CAS), drill template, surgical guides