This paper describes a step-by-step technique for the application of Emdogain, a new enamel matrix derivative (EMD) graft material, per periodontal reconstructive surgery. A case report is presented with a 1-year follow-up. The rationale for use and advantages and disadvantages of EMD are discussed. An additional human histologic case report demonstrates that the formation of new bone, cementum, and periodontal ligament is possible following the use of EMD.