Seiten: 323-332, Sprache: EnglischAbrahamsson, ngemar / Zitzmann, Nicola U. / Berglundh, Tord / Wennerberg, Ann / Lindhe, JanThe aim of the present experiment was to study the peri-implant soft and hard tissues formed at titanium implants with 2 different surface configurations and to give a topographic description of the surfaces examined. In 5 beagle dogs, the mandibular premolars were extracted. Three months later, 4 self-tapping standard implants (SI) and 4 Osseotite implants (OI) of the 3i Implant System were placed. The marginal 3 mm of the OI is turned, while the remaining part has an acid-etched surface structure. Abutments were connected after 3 months. A plaque control period was initiated, and after 6 months block biopsies were obtained. From each animal 2 units of each implant type were processed and embedded in EPON. The remaining biopsies were processed for ground sectioning. The histometric measurements performed on the EPON sections revealed that the peri-implant soft tissues and the marginal level of bone-to-implant contact were similar for SI and OI sites. In the ground sections, bone-to-implant contact (BIC%) and bone density assessments were made in 2 different zones. Zone I represented the contact area measured from the marginal level of bone-to-implant contact (B) to a position 4 mm above the apex of the implant, and zone II represented the apical 4 mm of the implant. For the SI sites, the BIC% was 56.1% in zone II and 58.1% in zones I + II. The corresponding figures for the OI sites were 76.7% and 72.0%. The BIC% was significantly larger at OI than at SI sites. Bone density values were similar at the SI and OI sites.
Seiten: 333-342, Sprache: EnglischLim, Young Jun / Oshida, Yoshiki / Andres, Carl J. / Barco, Martin T.The attachment of cells to titanium surfaces is an important phenomenon in the area of clinical implant dentistry. A major consideration in designing implants has been to produce surfaces that promote desirable responses in the cells and tissues. To achieve these requirements, the titanium implant surface can be modified in various ways. This research was designed to elucidate the relationship between surface roughness (Ra) and contact angle (Ø) of various engineered titanium surfaces of commercially pure titanium, titanium-aluminum-vanadium alloy (Ti-6Al-4V), and titanium-nickel (TiNi) alloy. The contact angle was measured using distilled water, 1% sodium chloride solution, human neutrophils, and osteoblast-like cells. Surface oxide crystallography was identified by transmission electron diffraction. It was found that: (1) there were no significant differences in contact angles among the 4 media; (2) for commercially pure titanium, a combined treatment (hydrofluoric acid/nitric acid/water sodium hydroxide oxidation) showed the lowest Ø (10.51 degrees in water), while the surface treated with sulfuric acid showed the highest value (72.99 degrees in water); (3) for all commercially pure titanium samples, when Ø is greater than 45 degrees, the contact angle increases linearly with Ra (hydrophobic nature) and the surface is covered with rutile-type oxide only, while the contact angle decreases linearly with Ra when Ø is less than 45 degrees (hydrophilic nature) and the surface is covered with a mixture of rutile and anatase oxides; and (4) a similar trend was found on Ti-6Al-4V and TiNi surfaces.
Seiten: 343-354, Sprache: EnglischArx, Thomas von / Cochran, David L. / Hermann, Joachim S. / Schenk, Robert K. / Higginbottom, Frank L. / Buser, DanielThe present study investigated the osseointegration of dental implants with a titanium plasma-sprayed surface (TPS) in regenerated and native bone in an experimental dog study. Initially, lateral bone defects were created in the alveolar ridge on both sides of the mandible. Two months later, lateral ridge augmentation was performed with (1) autogenous corticocancellous block grafts, (2) autogenous corticocancellous block grafts and e-PTFE membrane, (3) tricalcium phosphate particles and e-PTFE membrane, or (4) canine-derived demineralized freeze-dried bone allograft particles and e-PTFE membrane. After 4 months, membranes were removed, and non-submerged titanium implants were placed in regenerated bone (test implants) and in native bone (control implants). Two months later, the animals were sacrificed and non-decalcified orofacial sections were evaluated histometrically. All implants demonstrated high percentages (59% to 75%) of bone-to-implant contact, with no significant differences across the various treatment groups. The different grafting techniques did not significantly influence the location of first bone-to-implant contact and the horizontal bone width at the most coronal bone level.
Seiten: 355-366, Sprache: EnglischZitzmann, Nicola Ursula / Schärer, Peter / Marinello, Carlo PaoloThe aim of this prospective 5-year longitudinal study was to follow endosteal implants in which guided bone regeneration (GBR) was applied during implant placement. In 75 patients, defects around implants (Brånemark System) were treated with Bio-Oss and Bio-Gide (112 implants). In split-mouth patients in this group, Bio-Oss and Gore-Tex were used in the second defect site (41 implants). All 75 patients had at least 1 implant that was entirely surrounded by bone and served as the control (112 implants). After placement of the definitive prostheses (single-tooth, fixed, or removable implant prostheses), patients were recalled after 6 months and then every 12 months during a 5-year observation period. The following variables were investigated: implant survival, marginal bone level (MBL), presence of plaque, peri-implant mucosal conditions, height of keratinized mucosa (KM), and marginal soft tissue level (MSTL). The cumulative implant survival rate after 5 years varied between 93% and 97% for implants treated with or without GBR. The mean MBL after 60 months was 1.83 mm for sites treated with Bio-Oss and Bio-Gide, 2.21 mm for sites treated with Bio-Oss and Gore-Tex, and 1.73 mm for the control sites. The MBL values were found to increase significantly with time and differed significantly among the treatment groups. During the observation period, KM varied between 3.16 and 3.02 mm. A slight recession of 0.1 mm was observed, and plaque was found in 15% of all sites and was associated with inflammatory symptoms of the peri-implant mucosa. It was observed that such symptoms and recession correlated more strongly with the type of restoration than with the type of treatment. This study demonstrated that implants placed with or without GBR techniques had similar survival rates after 5 years, but that bone resorption was more pronounced in sites with GBR treatment. It was assumed that the use of GBR is indeed indicated when the initial defect size is larger than 2 mm in the vertical dimension.
Seiten: 367-377, Sprache: EnglischTan, Keson B. / Nicholls, Jack I.This study measured the screw joint preload of the implant-abutment interface for 7 common hex-top abutment systems. Increasingly, prosthetic designs are utilizing a direct prosthetic connection to the implant, placing the implant-abutment screw joint under direct functional loads and moments. Sufficiently high screw joint preloads are required to maintain screw joint integrity and confer clinical longevity to implant prosthetic components to prevent such complications as abutment screw loosening and screw fracture. Strain-gauged abutment load cells were calibrated to measure screw joint preload at the implant-abutment interface. Torque delivery by electronic torque controller was varied at low- and high-speed settings. At manufacturer's recommended torques, the overall mean preload measured was 181.6 ± 60.0 N for the Nobel Biocare Standard abutment, 291.3 ± 41.2 N for the Nobel Biocare EsthetiCone abutment, 456.5 ± 44.0 N for the Nobel Biocare MirusCone abutment, 369.7 ± 32.9 N for the 3i Titanium Abutment post, 643.4 ± 143.1 N for the Nobel Biocare CeraOne abutment, 536.3 ± 68.6 N for the Nobel Biocare "Gold Cylinder to Fixture" abutment, and 556.9 ± 145.6 N for the Nobel Biocare TiAdapt abutment. Analysis of variance revealed significant differences between abutment systems (P .001) and between torque driver speed settings (P .001). Implant-abutment screw joint preload of external-hex implants is dependent on abutment design, screw diameter, material, tightening torque, and torque controller speed.
Seiten: 378-388, Sprache: EnglischSethi, Ashok / Kaus, ThomasThe aim of the current ongoing study is to evaluate the long-term results of endosseous implants placed into autogenous bone grafts from intraoral donor sites. Patient selection for the correction of bone deficiencies was based on biomechanical and esthetic needs. Donor site selection was dependent upon the type of deficiency and the graft shape needed. Two-stage implants were placed after a healing period of 3 to 6 months, based on an assessment of the graft viability with radiographic and clinical parameters. Thus far, 118 implants have been placed in 60 patients whose alveolar ridges were deficient in height, width, or both height and width and were augmented. The patients were observed for up to 77 months. Two implant failures were encountered before implant exposure (1.7%). No further implants have been lost in function.
Seiten: 389-393, Sprache: EnglischCornelini, Roberto / Artese, Luciano / Rubini, Corrado / Fioroni, Massimiliano / Ferrero, Giuseppina / Santinelli, Alfredo / Piattelli, AdrianoInflammatory infiltrate may be important in the evolution of inflammatory processes involving peri-implant tissues. Angiogenesis is an important feature of inflammation and healing, but its role in the development and progression or in the healing of periodontal lesions has not been elucidated. Vascular endothelial growth factor (VEGF) is a potent inducer of endothelial cell proliferation. The aim of the present study was to conduct a comparative immunohistochemical evaluation of VEGF and microvessel density (MVD) in normal keratinized gingiva and in peri-implant soft tissues surrounding failing implants. Fifteen patients participated in this study. Ten biopsies were taken from healthy keratinized gingiva, and 10 were taken from peri-implant soft tissues surrounding failing non-submerged implants. In healthy sites, the endothelial lining cells of the vessels always tested positive for VEGF; also, VEGF intensity was high in most cases. Stromal cells were positive for VEGF in 70% to 90% of samples. The MVD was 60.250 ± 5.123. In peri-implantitis samples, the cells of the inflammatory infiltrate were positive for VEGF in 80% to 100% of cases, and the VEGF intensity was low in all cases. The stromal cells were positive for VEGF in 90% to 100% of cases, and in most cases the intensity was low. The MVD was 101.800 ± 11.256. The difference in MVD between healthy sites and peri-implantitis was statistically significant (P = .0158). Expression of VEGF was lower in peri-implantitis samples, and this difference was statistically significant (P = .0373). Because of its extensive presence, VEGF is probably a factor in both the maintenance of periodontal physiology and in the progression of peri-implant inflammatory disease.
Seiten: 394-399, Sprache: EnglischMitrani, Ricardo / Nicholls, Jack I. / Phillips, Keith M. / Ma, TsunTightening of the screws in implant-supported restorations has been reported to be problematic, in that if the applied torque is too low, screw loosening occurs. If the torque is too high, then screw fracture can take place. Thus, accuracy of the torque driver is of the utmost importance. This study evaluated 4 new electronic torque drivers (controls) and 10 test electronic torque drivers, which had been in clinical service for a minimum of 5 years. Torque values of the test drivers were measured and were compared with the control values using a 1-way analysis of variance. Torque delivery accuracy was measured using a technique that simulated the clinical situation. In vivo, the torque driver turns the screw until the selected tightening torque is reached. In this laboratory experiment, an implant, along with an attached abutment and abutment gold screw, was held firmly in a Tohnichi torque gauge. Calibration accuracy for the Tohnichi is ± 3% of the scale value. During torque measurement, the gold screw turned a minimum of 180 degrees before contact was made between the screw and abutment. Three torque values (10, 20, and 32 N-cm) were evaluated, at both high- and low-speed settings. The recorded torque measurements indicated that the 10 test electronic torque drivers maintained a torque delivery accuracy equivalent to the 4 new (unused) units. Judging from the torque output values obtained from the 10 test units, the clinical use of the electronic torque driver suggests that accuracy did not change significantly over the 5-year period of clinical service.
Seiten: 400-411, Sprache: EnglischMatin, Khairul / Nakamura, Hiroaki / Irie, Kazuharu / Ozawa, Hidehiro / Ejiri, SadakazuResidual ridge resorption begins following tooth extraction and continuously reduces alveolar bone volume, potentially creating a significant problem in dental implant treatment. In this study, the role of recombinant human bone morphogenetic protein-2 (rhBMP-2) in residual ridge resorption after tooth extraction was investigated. A polylactic acid/polyglycolic acid copolymer-coated gelatin sponge carrier was implanted with or without rhBMP-2 (1 µg) in the mesial root sockets after removal of maxillary first molars in male Wistar rats. Fine structural and histomorphologic analyses were conducted 3 to 84 days after implantation. Direct bone formation was first observed after 5 days on the rhBMP-2 side, which was transformed into cortical alveolar ridge with a smooth periosteal layer by 84 days, whereas the control side displayed slower healing. Bone histomorphometry revealed greater total bone area and increased bone height after 14, 28, 56, and 84 days on the rhBMP-2 side compared to the control side, and differences were significant after 14, 28, and 56 days. Larger numbers of proliferating cells and densely populated differentiating mesenchymal cells were observed on the rhBMP-2 side than on the control side in the early stage, and chondrogenesis was not observed. The findings indicate that rhBMP-2 may stimulate proliferation and differentiation of mesenchymal cells in the rat maxillary root socket to preserve cortical bone volume in the socket without any evidence of chondrogenesis.
Seiten: 412-417, Sprache: EnglischAyangco, Lilibeth / Sheridan, Phillip J.Osseointegrated implants provide predictable restorative support for crowns, restorations, prosthesis abutments, and removable dentures. Their widespread use in recent years has produced different types of complications. Retrograde peri-implantitis, a lesion occurring at the periapical area of an osseointegrated implant, has recently been described. This paper presents a series of reports describing the occurrence and management of retrograde peri-implantitis involving implants replacing teeth with histories of failed endodontic and apicoectomy procedures.
Seiten: 418-426, Sprache: EnglischGaneles, Jeffrey / Rosenberg, Marvin M. / Holt, Robert L. / Reichman, Linda H.Numerous authors have documented clinical success in loading threaded implants at the time of implant placement when carefully controlled surgical and restorative protocols are followed. This clinical series documents the application of immediate loading techniques to fixed mandibular restorations in 27 patients who were edentulous or had non-restorable mandibular dentitions. Eighteen patients had complete conventional maxillary dentures, while 9 had natural or fixed prosthetic maxillary dentitions. Twelve different restorative dentists provided prosthetic support for these patients and used 4 different restoration types: laboratory- or office-processed, with cement or screw retention. Five to 8 threaded implants were placed in each patient. One hundred sixty-one of the 186 implants that were placed by the authors were loaded immediately using fixed provisional restorations of the various designs. More than 99% (160/161) of the immediately loaded implants and 99.5% (185/186) of all implants were clinically integrated and radiographically successful at the time of final evaluation for restoration fabrication. After final implant evaluation, no additional implant losses occurred, indicating an implant survival rate of nearly 100% over a mean of 25.0 months (range 13 to 41 months) following implant placement. While a strong preference for cement-retained restorations was apparent, all prostheses showed similar success. The data and the experience described in this report indicate that immediate loading with fixed restorations using appropriate surgical and restorative techniques can be a predictable technique for rehabilitation of the completely edentulous mandible.
Seiten: 427-432, Sprache: EnglischMaiorana, Carlo / Santoro, Franco / Rabagliati, Marco / Salina, SergioThe present article describes a titanium mesh procedure used for bone augmentation in the treatment of severe maxillary atrophy. A mix of iliac cancellous bone and anorganic bovine bone in a 1:1 ratio is proposed for achieving the best bone quality at the time of implant placement, which is performed 5 to 6 months after the augmentation surgery. This procedure provides for 3-stage surgery using a titanium mesh (which is removed 4 to 5 months later) to retain the cancellous bone/Bio-Oss mixture. Bone specimens taken 5 to 6 months after the augmentation procedure showed bone regeneration and the presence of vessels, indicating bone vitality.
Seiten: 433-435, Sprache: EnglischPeñarrocha, Miguel / Sanchis, Jose Maria / Rambla, Javier / Guarinos, JuanIdiopathic torsion dystonia is a motor syndrome characterized by dystonic movements and postures in the absence of other neurologic deficits. The condition involves prolonged spasms of muscle contraction that distort the body into typical postures. Such distortions involving the head and the neck make conventional denture use in edentulous patients very difficult. The present paper reports on a patient with idiopathic torsion dystonia who was treated with a mandibular overdenture supported by endosteal implants, which enabled the establishment of a stable occlusion and improved the dynamics of the masticatory muscles for chewing.